SF Missions La Rondalla Closed

first_img 0% La Rondalla, the Mexican restaurant and cantina at 901 Valencia St., closed down quietly sometime last week and posted a handwritten note in its storefront window informing patrons of its closure. The inconspicuous note thanked the community for its patronage and appeared to have been posted some time before the weekend, but as of Monday, it had been taken down. “We are closing – God Bless you,” the note read. “P.S. We Love you all.”Luna Barrios, who along with her sister had managed the 64-year-old family business after it returned from a seven-year hiatus in 2014, declined to confirm whether the closure was permanent or to speak about what led to it. “We are figuring out what to do with the space for the time being,” said Barrios. Neighbors confirmed that service had been halted at the restaurant since last week.“They haven’t been open in the last week, maybe a little longer,” said Melissa Richmond, an employee at Dog Eared Books at 900 Valencia St, directly across the street from La Rondalla. “I was surprised because there are a lot of soccer games going on right now and they usually draw in crowds for that.” Known for its potent margaritas, mariachis and year-round Christmas decorations, La Rondalla became a Mission classic that attracted families during the day and fed late-night bar goers at hours when many other restaurants in the area stopped serving.  The story of La Rondalla began in 1951, when Carlos and Esperanza Barrios first opened in the 2,500 square-foot restaurant space on the ground-floor of a building on the corner of 20th and Valencia streets, which they purchased in the 1990s.During its early years, the restaurant became somewhat of an unofficial hangout for gay Latinos and  featured performances by transgender artist and mariachi singer Alberta Nevaerez, who was better known to the community as “Teresita la Campesina,” according to Preserving LGBT Historic Sites in California, an online archive dedicated to memorializing places associated with LGBT history throughout the state. The group first posted about La Rondalla’s closure on Facebook on July 24. In the late 1980s, ownership was delegated to Barrios’ son, Carlos Cruz Barrios, who ran the restaurant for some 20 years and also inherited the building.Despite its longstanding history in the community, this is not the restaurant’s first closure.In 2007, the Health Department moved in to shut down the establishment following several violations that included a rodent infestation. For years, the space lay dormant as the family scrambled to meet health codes and underwent renovations. Barrios turned down multiple offers to sell the space, and in 2011 transferred the restaurant’s ownership to his daughters, Luna and Betty, following his own health scares.“I’m not going to be around forever,” Barrios told Mission Local in 2011.Still, announcements of a grand re-opening were followed by years of delay. In 2012, Luna cited “financial troubles” and bureaucratic delays reasons for La Rondalla’s years-long hiatus. The Barrios family faced additional problems in 2015 when the city sued them after tenants alleged that they were struggling to keep up with their obligations as landlords.  When La Rondalla was finally resurrected in May 2014, the restaurant faced an immediate setback when original chef Mario Hernandez died on Valencia street that same month. But the Barrios family was determined to keep the family business going, and invested over $500,000 in renovations that included outfitting its bar with flat screen TVs replacing and more modern decor – bright orange walls and lively artwork.It is unclear what will happen with the space or if a future resurrection under the family name is in La Rondalla’s cards. We will update the story once we know more. center_img Tags: restaurants Share this: FacebookTwitterRedditemail,0%last_img read more

TICKETS for Super Leagues Magic Weekend are now o

first_imgTICKETS for Super League’s Magic Weekend are now on sale – and at prices that are too good to miss.Returning to the Etihad Stadium, Manchester, following a successful visit in 2012, all 14 Super League clubs will again be in action over the weekend of Saturday May 25 and Sunday May 26 and season ticket holders can take advantage of 50 per cent off!Saints will take on Warrington on the Saturday and have already got one over their rivals this season.The Magic Weekend 2013 opens at noon on Saturday May 25 with Catalan Dragons versus London Broncos before local rivals Castleford Tigers and Wakefield Trinity Wildcats go head to head from 2.15pm.Local bragging rights will be no more valuable than in the third match on Saturday, with the Hull derby kicking off at 4.30pm before St Helens and Warrington Wolves provide the final Rugby League showpiece from 6.45pm.Sunday’s action gets underway at 3.00pm with Salford City Reds clashing with Widnes Vikings followed by Bradford Bulls and Huddersfield Giants facing each other at 5.15pm.A memorable weekend will reach a crescendo with the battle between Grand Final winners Leeds Rhinos and 2012 League Leaders Wigan Warriors from 7.30pm.You can buy your ticket from the Ticket Office at Langtree Park, by calling 01744 455 052 or by logging on here.Prices are:Category  Reserved Seating  Unreserved Seating Adult Conc AdultConc   Daily Regular £45 £22.50 £30 £15 STH £22.50 £11.25 £15 £7.50  Weeekend Regular £60 £30 £45 £22.50 STH £30 £15 £22.50 £11.25last_img read more

MEET David RoeHe has raised close to £1000 for S

first_imgMEET David Roe!He has raised close to £1,000 for St Helens Autism Support by shaving his head.Inspired by our new Magic shirt, he lost is luscious locks – and handed over the results of his spoils to Mike Denning from the charity and the Saints’ squad last week.“Firstly I would like to say a massive thank you the Saints and St Helens Autism Support for making me and my wife Angie so welcome,” David said. “I would also like to thank my daughter Kirsty and Mike Appleton for organising the visit, of which I had no idea I was going to meet the team. I was honoured to be allowed in and be able to watch them train before the game against Salford.“Being at the time a rugby union fan, my love of rugby league began four years ago, when my other daughter Kelly bought me a rugby league shirt for Christmas. Not to disappoint her I promised I would attend a game. So I booked tickets for myself and Angie not knowing what to expect or even knowledge of the rules.“To my delight from the kick off we were hooked and have visited most of the league grounds on our travels. I was taken in by the speed at which the game is played; it is literally end to end non-stop. The fitness and commitment of all the players is a credit to the sport. We have had great pleasure meeting various supporters and enjoying a friendly drink and banter with them after the games. I would recommend any Union supporter to go and see for themselves, they will not be disappointed.“The highlight of following league was last year when we attended the Magic Weekend, what a spectacle! Twelve sets of fans at one venue all having a good time enjoying the atmosphere and banter with the bonus of six absolutely brilliant games. I enjoyed it so much I was almost sad to see it end.“Which leads me onto St Helens Autism Support. Last year we supported the Bobby Robson trust by purchasing the shirt. I had been growing my hair for sixteen months to have it shaved and raise money for autism. Autism is close to our hearts with Lewis on Angie’s side of the family and Kirsty is godparent to Max.“That decided, I heard via the Saints that this year they were supporting autism by the sale of their shirts. I thought it would be a nice gesture being a fan, to donate my sponsorship money to St. Helens Autism Support.“After all the club gives so much to the community it’s rewarding to be able to support the team, not only on the pitch but off as well.“Autism is now gaining more and more recognition and publicity, with the support of a great team like St Helens, it will continue to do so.”last_img read more

We wont stop Victims family in SC transport van case wants policy

first_img One of those women was Allison and Charles’ mother.Now-former correctional officers Stephen Flood and Joshua Bishop survived but were unable to save Wendy Newton, 45, of Shallotte, and Nicolette Green, 43, of Myrtle Beach.Flood and Bishop have been fired and charged.Related Article: Wilmington Mayor: ‘Once it’s upon us, we can’t save you’“We don’t want anybody to go through what we’ve been through and are still going through. It’s not like, just like it’s passed and gone. It’s still an every day thing. This was our mother. It’s not going to go away, so we can do as best as we can to make sure other kids don’t have to lose their mom, their dad” Charles said.Read more here. Interview with Wendy Newton’s family. (Photo: WPDE) TABOR CITY, NC (WPDE) — Allison and Charles Newton’s lives forever changed on Sept. 18 when their mother, Wendy Newton, drowned in the back of an Horry County Sheriff’s Office transport van.It happened in the days following Hurricane Florence when two Horry County Sheriff’s Office correctional officers drove through flood waters with two mental health patients trapped in the back.- Advertisement – last_img read more

UNCW Presents and Opera Wilmington gearing up for 3rd Annual Lumina Festival

first_img “We’re really excited to be bringing Rhiannon Giddens of Carolina Chocolate Drops fame back to the stage along with acclaimed jazz artist Regina Carter and award-winning author Jeremiah Sullivan who will be collaborating on a piece called ‘Lost Love Song,’” said UNCW Marketing and Communication Specialist Emmanuel Mitcham.Some of the other performances will include Opera Wilmington’s La Boheme and a Shakespearean performance by Alchemical Theatre’s group, Make Trouble. Other fun events include a poetry jam and a Salsa party.The festival will also present a street fair called Hooked on Arts on July 13-14 to be held outside UNCW’s Kenan Auditorium.“It’s a celebration of the healing aspect of the arts as it pertains to arts-based therapy and this event is a collaboration of UNCW’s College of Health and Human Services and the Office of the Arts,” Mitcham said.Hooked on Arts is free to the public and features art vendors, food trucks and entertainment with Mr. Mark and Mr. Scooter.Tickets to the festival range from $10-$50 depending on the performance.“There’s something for everyone here and once again I’d like to highlight how affordable it is, there’s a whole slew of free events,” Mitcham said. “We want everybody to come out.”To learn more about the Lumina of the Arts Festival or to purchase tickets, click here. WILMINGTON, NC (WWAY) — The Lumina Festival of the Arts, presented by UNCW Presents and Opera Wilmington, celebrates the arts in the coastal south and it’s coming here to Wilmington.The festival takes place July 12-28 and features opera, theatre, dance, film, music, visual art and performance poetry.- Advertisement – last_img read more

Holly Grange announces shes entering 2020 governors race

first_imgHolly Grange (Photo: Holly Grange) RALEIGH, NC (AP) — A North Carolina state legislator has entered the 2020 gubernatorial race, providing a rival in the Republican primary for Lt. Gov. Dan Forest, who’s been preparing for years to seek the party’s nomination.State Rep. Holly Grange of Wilmington announced her candidacy on Thursday in a campaign video. Grange called herself a “pro-business law-and-order, Trump-supporting conservative.”- Advertisement – The Republican nominee is likely to take on Democratic Gov. Roy Cooper, who is planning a re-election bid.Grange has served in the legislature since 2016. Her video touched on themes designed to connect with the state party’s conservative base, including immigration, abortion and gun rights.In an interview, she downplayed differences with Forest, but says it’s good for primary voters to have a choice, and ultimately her campaign is about unseating Cooper.last_img read more

Manchester United succumb to second league defeat

first_img SharePrint <a href=’http://revive.newsbook.com.mt/www/delivery/ck.php?n=a7617b59&amp;cb={random}’ target=’_blank’><img src=’https://revive.newsbook.com.mt/www/delivery/avw.php?zoneid=128&amp;cb={random}&amp;n=a7617b59&amp;ct0={clickurl_enc}’ border=’0′ alt=” /></a> Tottenham Hotspurs outclassed Manchester United in today’s Premier League match as Mauricio Pochettino’s side scored three goals at Old Trafford.England international Harry Kane scored his second goal of the new season with a header at the begin of the second half after a goalless 45 minutes. Lucas Moura increased Tottenham’s advantage two minutes later thanks to a low shot following a precise pass by Christian Eriksen.Things went from bad to worse for Jose Mourinho’s side as Moura scored his second of the evening after defender Chris Smalling failed to stop the former Paris Saint Germain forward from beating a helpless David De Gea.WhatsApplast_img read more

ACI Uganda Introduces Initiative to Drive Financial Literacy Among Disadvantaged Communities

first_imgMr Benoni Okwenje, the new Chairman of the ACI Financial Markets Association of Uganda. Advertisement ACI Uganda over the weekend announced a new partnership with its members as well as different stakeholders to give back to the community. ACI Uganda’s membership consists of dealers in the treasury departments of commercial banks.The members of ACI Uganda, through the 24 commercial banks in the country, drive market growth, awareness and development.Speaking at the dinner at Golden Tulip in Kampala, ACI Uganda Chairman and Stanbic Bank Uganda’s Head of Fixed Income; Benoni Okwenje said the association believes extending kindness to the community is the only investment that never fails. – Advertisement – “We were given two hands, one to help ourselves and the other to help others,” said Benoni.In 2016, the association was able to raise UGX34 million for the Bless a Child Foundation, a home for children living with Cancer. This year, the proceedings will go to Salama School for the Blind because most of the children cannot afford specialized scholastic materials. TFK-Read-Write School clubs, on the other hand is instrumental in raising the deteriorating reading and writing culture throughout Ugandan schools.“We’re grateful to ACI Uganda for taking the initiative to support our students so they can access these materials and perform better in their studies,” said Francis Kinubi; Head teacher and Co-Founder of Salama School.Francis said books and other scholastic materials for the blind at all levels of education are hard to come by in Uganda. He further added that most parents of these blind students are poor and therefore cannot afford these resources.Mr Benoni Okwenje (L), the Chairman ACI Uganda interact with Mr Francis Kinubi (R), the Salama School of the Blind Co-founder and Headmaster during the launch of the association CSR initiative towards the school.TFK-Read-Write School Clubs Patron Director Frank Kabushenga added in his remarks said, they’ve carried out several projects over the years which include, setting up read and write clubs in a dozen schools, providing reading materials to the club and the publication of various books by local writers and more.“This support from ACI will ensure that we realize our dream of rolling out this program across the entire country,” he said.Incorporated in 2015, ACI Uganda serves Uganda’s financial sector and is affiliated to ACI Financial Markets Association (ACIFMA), the global body established in 1955 that is focused on enhancing best market practice and supporting financial market participants to adhere to principles of ethical conduct.last_img read more

BENS BLOG Long Live the Star Army

first_img[dropcap]B[/dropcap]log, I don’t know what’s happening at the moment, but we, The Star Army, are falling, all over the place..!Stevie ‘Sex-Shop’ Warner (pictured, right), one of our most loyal soldiers, from Leicester, has, most unreasonably, had to nick an unsuspecting passer-by’s kidney.And what the bloody-hell’s wrong with young Lewis Brown.? He’s only a baby..! Poor Lewis, has had to have a large lump removed, and I’m not just talking about a pile of his dad, bookmaker, Bo’s, huge amount of readdies..!!We send our love to both…In other news:I write to you, from a taxi, on the way to Heathrow. I’m off to Spain, with Belindabelle, for an enforced Group-Socialising-and-Family-Stuff Holiday. But to take some of the pain away, (as I’m the most fidgety and annoying traveller in the whole World – as you can imagine, I’m sure!), we’ve organised a right old coup. BA flights. Yes, Blog! THANK GOD; the last outpost of hope, for any Not-Staff; British Airways. Us Fat-Whiteys need room to spread out, you know? Yes, yes..you still have to do the journey, so what’s the difference really? Not having to sit near any Unpleasant-Puntery-Types: THAT’S THE DIFFERENCE, BLOG.!!Over and out, B xlast_img read more

STARTERS ORDERS Weds Movers and Specials

first_imgWelcome to Starters Orders. Julie Collier with our daily midday update from the trading room at Star Sports with our key market movers for the day across all sports.Wednesday 24 OctoberJULIE COLLIER Introduces the afternoon daily specials and offers on Wednesday:<span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span>SARAH KINSELLA Introduces the evening daily specials and offers on Wednesday:<span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span> HORSE RACING2.35 NewmarketLight And Dark 15/8 > 5/43.00 WorcesterGunfleet 4/1 > 2/15.10 FontwellA Little Chaos 11/2 > 11/4LIVE FOOTBALLUEFA Champions League Group Stage20:00 BT Sport ESPN8/15 Barcelona21/4 Inter Milan10/3 DRAWUEFA Champions League Group Stage20:00 BT Sport 2 / BT Sport 4K UHD1/12 Liverpool28/1 Crvena Zvezda11/1 DRAWBET NOW starsports.bet or 08000 521 321last_img read more

Rice Geologists Find Evidence Fault Cuts Down to Mantle

first_imgAddThis Share CONTACT: Lia Unrau PHONE: (713) 831-4793 E-MAIL:unrau@rice.eduRICE GEOLOGISTS FIND EVIDENCE FAULT CUTS DOWN TO MANTLEThe northern San Andreas fault extends through theEarth’s lower crust and through the Moho, the boundary layer between the crustand the mantle of the Earth, two Rice University researchers and a colleaguefrom Virginia Tech found.The geologists recently studied the northernmost part of the San Andreasfault system in northern California.It is the first time scientists have evidence that what is happening at thesurface in this area&emdash;strike-slip faulting&emdash;is also takingplace to depths as great as the upper mantle. This strike-slip fault system iswhere the Pacific and North American plates slide by one another.The findings show that a layer in the lower crust is offset vertically at itstop and its base in the vicinity of two faults in the region, suggesting thatthe surface strike-slip deformation extends down into the upper mantle, saidAlan Levander, Rice professor of geology and geophysics. “This is one importantobservation in a number of findings resulting from a large-scalemulti-institutional study of the Triple Junction region,” he said.Timothy Henstock, research scientist at Rice University, said, “We are thefirst to look in detail at the structure in this region. Our results give a goodframework within which to understand the earthquakes which are occurring.”The findings have been published in a paper titled, “Deformation in the LowerCrust of the San Andreas Fault System in Northern California,” which appears inthe Oct. 24 issue of Science. The paper was co-authored by Henstock, Levanderand John Hole, assistant professor of geological sciences at VirginiaPolytechnic Institute.In the future, the findings may also help scientists understand links betweenwhat kind of earthquakes happen and the structures below the surface, Henstocksaid.The San Andreas fault system, which at the northern latitude is made up ofthree faults, is expanding northward parallel to the California coast at alocation called the Mendocino Triple Junction — where the edges of the Pacific,North American and Gorda plates rub together.“This finding is important because we’re looking at a very early stage in theevolution of the San Andreas Fault system,” Henstock said. “We’re much closer towhere the initial active process is taking place, and this helps us deduce howactivity in the crust and in the mantle relate to one another.”Levander said, “It appears that processes in the mantle are controlling thedeformation process directly above in the upper crust.”The San Andreas fault started in southern California about 27 million yearsago, but at this location, about 100 miles south of the Mendocino TripleJunction, it is relatively young — only two million years old. Learning aboutthe evolution of the fault system and how it is moving northward may helpscientists understand how the fault evolved in the San Francisco area. Thefinding provides evidence against the suggestion that the three major faultswhich make up the San Andreas fault system are connected at shallow depths whenthe fault system is young.The study made use of marine, off-shore and land seismic reflection andrefraction surveys of the deep crust, 15-19 miles down, for the full width ofthe fault system from east to west — about 120 miles. Looking at data collectedusing three independent methods, the researchers came to the same conclusion ineach instance.Levander and his colleagues think that the Gorda plate, which is fragmenting,is being pushed east, breaking up underneath the North American plate andsticking to the underside. Some fragments are as large as a room; others are thesize of a city like Houston. The Rice researchers believe that this is the mostprobable cause of the offset crust.The research was funded by the National Science Foundation’s ContinentDynamics Program, and included researchers from Oregon State University, LehighUniversity, Stanford University, and the United States Geological Society, aswell as Rice and Virginia Tech.###last_img read more

Rice Linguists Study Native Languages in Brazilian Jungle

first_imgAddThis Share CONTACT: Philip Montgomery PHONE: (713)831-4792E-MAIL: pmontgom@rice.eduRICE LINGUISTS STUDY NATIVE LANGUAGES IN BRAZILIAN JUNGLELike an old-time traveling medicine show, Ricelinguist Spike Gildea and his team of Rice graduate students show up everysummer in jungle villages in Brazil playing guitars and offering trade goods.The deal is simple. Gildea trades fishhooks and cloth for stories and time.He has two purposes: documenting living languages of indigenous people whoseways of life are threatened by encroaching Western civilization; and spreadingword among natives of the threat of AIDS, which caused the first official deathamong northern Brazilian Indians last year.Gildea, an associate professor of linguistics, received a three-year NationalScience Foundation grant in 1992 to study the Cariban family of languages inBrazil. Additional grants from Rice allowed him to stretch the funding throughthe summer of 1997. He concluded the first phase of his research in August andnow will take some time to write for publication.The team has been working in northern Brazil studying 10 of about 25languages of the Cariban family spoken in a geographic area stretching fromsouthern Columbia across to Venezuela and the Guianas to well south of theAmazon River. The territory is hostile and remote.Aside from snakes and large insects that bite, there are numerous parasitesand fierce diseases. In addition, the native speakers are known for beingaggressive and are reputed to have been cannibals, a practice they haveapparently given up under pressure from contact with Westerners. But Gildea hasmanaged to make numerous friends among the tribes.###last_img read more

Study shows that defensive military alliances enhance peace

first_imgShareCONTACT: David RuthPHONE: 713-348-6327EMAIL: druth@rice.eduStudy shows that defensive military alliances enhance peaceCountries that enter into defense pacts with other nations are less likely to be attacked, according to new research from Rice University. And those countries are not more likely to attack others.The study, “Defense Pacts: A Prescription for Peace?”, was published recently in the journal Foreign Policy Analysis. It was co-authored by Rice University Associate Professor of Political Science Ashley Leeds and Jesse Johnson, a Rice graduate student in political science. For their research, Leeds and Johnson did exhaustive analysis of defense agreements from 1816 to 2001 that covered the whole world.“We were interested in analyzing policy prescriptions that leaders of countries can adopt that might make war — and also militarized conflicts short of war — less likely,” Leeds said. “War is costly, most importantly in terms of lives lost, but also in terms of financial resources, destruction of productive capacity and infrastructure, and disruption of trade. As a result, research aimed at discovering policies that can prevent war is valuable.“We found that when a country enters into a defense pact, it is less likely to be attacked,” Leeds said. “In addition, entering into defense pacts does not seem to make countries more likely to attack other states.” Leeds believes that this research has current policy relevance for the United States and other countries. “A current policy debate, for instance, is whether Georgia should be accepted as a new member of the North Atlantic Treaty Organization (NATO). If Georgia joins NATO, the U.S. and other NATO countries will be committing to assist Georgia if Georgia is attacked by another state, for instance, Russia. Some analysts are concerned about the U.S. making such a commitment, and some believe that having a commitment of assistance from the U.S. could encourage Georgia to behave aggressively toward Russia, making war more likely. The study suggests that this is not the most common general pattern. In fact, a defensive commitment to Georgia should, according to the study, make war between Russia and Georgia less likely.” Currently the United States has many defensive alliances, including with most of the Western Hemisphere states, NATO countries, Japan, South Korea and Pakistan, among others. The study suggests that due to their alliance with the U.S., these states are less likely to be attacked by rivals, and U.S. allies are no more likely to behave aggressively than they would be without a U.S. alliance commitment.The National Science Foundation and Rice University funded the research.To schedule an interview with Leeds, contact David Ruth, director of national media relations at Rice University, at druth@rice.edu or 713-348-6327. AddThislast_img read more

Cancer researchers find key protein link

first_imghttp://news.rice.edu/files/2014/03/0331_PROTEINS-2-web.jpgA combination of experimental and theoretical studies, in particular direct coupling analysis, revealed detailed interactions between NAF-1 (magenta) and Bcl-2 (blue), two proteins involved in cellular life-and-death decisions. (Credit: Mark Paddock, Patricia Jennings/UCSD)Located on a 300-acre forested campus in Houston, Rice University is consistently ranked among the nation’s top 20 universities by U.S. News & World Report. Rice has highly respected schools of Architecture, Business, Continuing Studies, Engineering, Humanities, Music, Natural Sciences and Social Sciences and is home to the Baker Institute for Public Policy. With 3,920 undergraduates and 2,567 graduate students, Rice’s undergraduate student-to-faculty ratio is 6.3-to-1. Its residential college system builds close-knit communities and lifelong friendships, just one reason why Rice has been ranked No. 1 for best quality of life multiple times by the Princeton Review and No. 2 for “best value” among private universities by Kiplinger’s Personal Finance. To read “What they’re saying about Rice,” go here. ShareDavid Ruth713-348-6327david@rice.eduMike Williams713-348-6728mikewilliams@rice.eduCancer researchers find key protein linkDiscovery could lead to new medications, according to Rice University scientists HOUSTON – (March 27, 2014) – A new understanding of proteins at the nexus of a cell’s decision to survive or die has implications for researchers who study cancer and age-related diseases, according to biophysicists at the Rice University-based Center for Theoretical Biological Physics (CTBP).Experiments and computer analysis of two key proteins revealed a previously unknown binding interface that could be addressed by medication. Results of the research appear this week in an open-source paper in the Proceedings of the National Academy of Sciences.The proteins are Bcl-2, well-known for its role in programmed cell death, and NAF-1, a member of the NEET family that binds toxic clusters of iron and sulfur. How the two interact is now known as a major determinant in the cell processes of autophagy and apoptosis — literally, life and death. An ability to uncover binding sites on the proteins that send the cell one way or the other opens a path toward the regulation of those processes, according to José Onuchic, Rice’s the Harry C. and Olga K. Wiess Chair of Physics and professor of physics and astronomy.Pockets and folds in proteins exist to bind to other molecules and catalyze actions in a cell in signaling pathways. The ability to block a specific binding site or to enhance a desired interaction is critical to drug design, Onuchic said.“In our early work we have shown the link between NEET proteins and cancer. Now we can understand the molecular details of how these interactions are governed,” Onuchic said. “Others have shown that NAF-1 is up-regulated in cancer cells, which leads us to believe that cancer may hijack control over the expression of this protein. This affects the cell’s system of checks and balances. Understanding NAF-1 gives us a better idea of how to approach treatment.”The researchers found that NAF-1 binds to two specific regions of the protein Bcl-2 and that Bcl-2 binds to the NAF-1 groove formed between the beta cap and iron-sulfur cluster binding domains; the strongest coupling is at the cluster binding domain and some contacts of interest are at the top of the beta-cap domain. Since the iron-sulfur cluster is the functional entity involved in NAF-1 activity, these findings clearly indicate that Bcl-2 interaction with NAF-1 affects its activity, Onuchic said.The research team used a unique combination of experimental and theoretical methods, including peptide array binding studies with fragments of Bcl-2 to NAF-1; the researchers performed functional studies of cluster transfer and other full-length protein interactions with a spectrometer sensitive to hydrogen/deuterium exchange. They combined their results with a computer-based process created at CTBP called direct coupling analysis (DCA), through which interactions between proteins can be predicted by their genomic roots.“Each of the three techniques not only confirmed the results of the other methods but also provided unique insights in their own right,” said Patricia Jennings, a lead author and CTBP affiliate based at the University of California, San Diego (UCSD), where she is a professor of chemistry and biochemistry.Jennings said the combined techniques are applicable to biomolecular interactions in general. “DCA helps us efficiently filter through massive amounts of data and does not require high-resolution structural studies, although those are desirable,” she said. “Peptide array is powerful for localizing fragments that bind with high affinity, and hydrogen/deuterium exchange studies allow us to monitor parts of the intact protein that are not seen in structural studies and are not amenable to DCA analysis.“Together, the techniques provide an exquisite synergy,” she said.Jennings is a co-lead author of the study with Onuchic; Rachel Nechushtai, a professor at the Alexander Siberman Life Science Institute of the Hebrew University of Jerusalem; Assaf Friedler, a professor at the Hebrew University Institute of Chemistry; and Ron Mittler, a professor of biological sciences at the University of North Texas, Denton (UNT). Previous research by the team identified NAF-1 as one of two prime suspects in the proliferation of breast cancer.“Once again, our international team of experts from different disciplines has shown that combined complementary efforts leads to innovative knowledge imperative for coping with cancer,” Nechushtai said.Co-authors are Sagi Tamir, Shahar Rotem-Bamberger and Chen Katz of Hebrew University; Faruck Morcos, a postdoctoral researcher at Rice; and Kendra Hailey, John Zuris, Charles Wang, Andrea Conlan, Colin Lipper and Mark Paddock, all of UCSD.The Israeli Science Foundation, the European Research Council under the European Community’s Seventh Framework Program, the National Institutes of Health and the Cancer Prevention and Research Institute of Texas supported the research.-30-Read the paper at http://www.pnas.org/content/early/2014/03/24/1403770111.abstractFollow Rice News and Media Relations via Twitter @RiceUNewsRelated Materials:Center for Theoretical Biological Physics: https://ctbp.rice.eduImages for download: http://news.rice.edu/files/2014/03/0331_PROTEINS-1-web.jpg A combination of experimental and theoretical studies, in particular direct coupling analysis (DCA), revealed detailed interactions between NAF-1 (left) and Bcl-2 (right), two proteins involved in cellular life-and-death decisions. The green lines represent links between the proteins predicted by DCA.center_img AddThislast_img read more

Rice expert available to comment on GOP South Carolina primary and how

first_imgAddThis Share1Rice UniversityOffice of Public Affairs / News & Media RelationsDavid Ruth713-348-6327david@rice.eduAmy McCaig713-348-6777amym@rice.eduRice expert available to comment on GOP South Carolina primary and how Scalia death will impact raceHOUSTON — (Feb. 16, 2016) – As the remaining Republican presidential candidates prepare for the Palmetto State’s crucial primary elections on Feb. 20, Texas political expert Mark Jones, a professor of political science at Rice University and fellow at Rice’s Baker Institute for Public Policy, is available to comment on how the various candidates might fare. He is also available to comment on how U.S. Supreme Court Justice Antonin Scalia’s sudden death may impact the race.Mark Jones photo courtesy Rice UniversityJones said that five of the six remaining GOP candidates have targets they will be working to reach and pitfalls they will be attempting to avoid in South Carolina.“Donald Trump roars into South Carolina fresh from his New Hampshire victory and striving to make it two in a row,” Jones said. “Ted Cruz, who in current polls is right on Trump’s heels in South Carolina, will attempt to take advantage of his appeal to evangelical Christians.”Jones noted that a Cruz victory in South Carolina could set the stage for similar success in the southern states from Georgia to Texas that contain the majority of the delegates in play on March 1 in what is being called the “SEC Primary.”Meanwhile, Jones said Marco Rubio’s goal is to rebound from a fifth place finish in New Hampshire with at least a third place finish in South Carolina.“Rubio wants to put as much separation as possible between himself and his rivals in the ‘establishment lane’, Jeb Bush and John Kasich,” Jones said. “By the same token Bush and his Right to Rise Super PAC are already taking advantage of their deep war chest to hammer Rubio with the maximum goal of surpassing him to finish third in South Carolina and the minimum goal of keeping the margin of any possible Rubio victory as small as possible.”Jones said that New Hampshire runner-up Kasich is expected to employ a more targeted strategy in the Palmetto State, focusing his meager resources on areas of the state with high concentrations of centrist conservative Republican primary voters, with the objective of being able to point to success winning some delegates, even while finishing in fifth place.Jones said that it is unclear why Ben Carson has not followed the lead of Mike Huckabee, Rand Paul, Rick Santorum, Carly Fiorina and Chris Christie and suspended his campaign after sub-par performances in Iowa and New Hampshire.“There is not even a glimmer of a path to victory for Carson, and in South Carolina all that awaits him is vote share somewhere in the single digits,” Jones said.Jones said that it is still unclear how the unexpected death of Scalia will affect the dynamics of the GOP primary.“While there is the potential that heightened partisan rhetoric and polarizing positions on whether to move forward with the confirmation process in 2016 or wait until the next president takes office could benefit the more conservative and partisan Cruz and adversely affect the more centrist Bush and Kasich, there is also a real possibility that Scalia’s death causes Republican primary voters to give greater weight to a candidate’s general election viability, that is, their prospects for defeating Clinton,” Jones said. “This is based on the logic that the next president will determine the ideological balance of the U.S. Supreme Court. It is something which would benefit Bush, Kasich and Rubio and adversely affect Cruz and Trump.”Jones is a leading expert on Texas politics. He has been quoted nationally about Cruz’s political career, which he has followed extensively since Cruz’s days as solicitor general of Texas to the launching of a long-shot U.S. Senate bid to today. To speak with Jones, contact him directly at 832-466-6535.Rice University has a VideoLink ReadyCam TV interview studio. ReadyCam is capable of transmitting broadcast-quality standard-definition and high-definition video directly to all news media organizations around the world 24/7.-30-This news release can be found online at http://news.rice.edu.Follow Rice News and Media Relations via Twitter @RiceUNews.Related materials:Mark Jones biography: http://bakerinstitute.org/experts/mark-p-jones/Mark Jones Twitter handle: @MarkPJonesTXMark Jones headshot: http://news.rice.edu/files/2014/09/mark-jones.jpgPhoto credit: Rice UniversityLocated on a 300-acre forested campus in Houston, Rice University is consistently ranked among the nation’s top 20 universities by U.S. News & World Report. Rice has highly respected schools of Architecture, Business, Continuing Studies, Engineering, Humanities, Music, Natural Sciences and Social Sciences and is home to the Baker Institute for Public Policy. With 3,910 undergraduates and 2,809 graduate students, Rice’s undergraduate student-to-faculty ratio is 6-to-1. Its residential college system builds close-knit communities and lifelong friendships, just one reason why Rice is ranked No. 1 for best quality of life and for lots of race/class interaction by the Princeton Review. Rice is also rated as a best value among private universities by Kiplinger’s Personal Finance. To read “What they’re saying about Rice,” go to http://tinyurl.com/AboutRiceUniversity.If you do not wish to receive news releases from Rice University, reply to this email and write “unsubscribe” in the subject line. Office of News and Media Relations – MS 300, Rice University, 6100 Main St., Houston, TX 77005last_img read more

How to revitalize public places Urban expert to discuss fostering community in

first_imgShareRice UniversityOffice of Public Affairs / News & Media RelationsMEDIA ADVISORYDavid Ruth713-348-6327david@rice.eduAmy McCaig713-348-6777amym@rice.eduHow to revitalize public places: Urban expert to discuss fostering community in cities at Rice eventHOUSTON – (Oct. 17, 2018) – On the heels of recent research showing Houstonians have higher levels of mistrust than the national average, urban expert Carol Coletta will discuss how cities can revitalize public places and encourage neighborhood interaction and civic engagement at an Oct. 24 talk hosted by Rice’s Kinder Institute for Urban Research. The event will take place at 7 p.m. at the Brown Auditorium Theater at the Museum of Fine Arts, Houston.Who:              Urban expert Carol ColettaWhat:             Kinder Institute Forum event.When:            7 p.m. Wednesday, Oct. 24.Where:           Brown Auditorium Theater at the Museum of Fine Arts, Houston, 1001 Bissonnet St.Coletta is president and CEO of the Memphis River Parks Partnership, where she is leading the relaunch of a nonprofit to develop, manage and program 6 miles of riverfront and five park districts along the Mississippi River. She is also a senior fellow in American Cities Practice at The Kresge Foundation.Coletta also leads Reimagining the Civic Commons, a $50 million-plus collaboration of national and local foundations, nonprofits and governments with projects in five cities. It is planned as the first comprehensive demonstration of how a connected set of civic assets — a civic commons — can help cities and neighborhoods grow and become more prosperous.Coletta also led the startup of ArtPlace, a unique public-private collaboration to accelerate creative placemaking in communities across the U.S., and was president and CEO of CEOs for Cities for seven years. Her full bio is available athttps://kresge.org/who-we-are/carol-coletta.The event is free and open to the public, but RSVPs are requested. For more information or to reserve a seat, visit https://bit.ly/2CEAfRu.Media interested in attending the event should contact Amy McCaig, senior media relations specialist at Rice, at 713-348-6777 or amym@rice.edu.-30-This news release can be found online at news.rice.edu.Follow Rice News and Media Relations on Twitter @RiceUNews.Photo link: http://news.rice.edu/files/2018/10/Carol-Coletta-1a0w7qm.gifPhoto credit: Submitted photo.Located on a 300-acre forested campus in Houston, Rice University is consistently ranked among the nation’s top 20 universities by U.S. News & World Report. Rice has highly respected schools of Architecture, Business, Continuing Studies, Engineering, Humanities, Music, Natural Sciences and Social Sciences and is home to the Baker Institute for Public Policy. With 3,970 undergraduates and 2,934 graduate students, Rice’s undergraduate student-to-faculty ratio is just under 6-to-1. Its residential college system builds close-knit communities and lifelong friendships, just one reason why Rice is ranked No. 1 for lots of race/class interaction and No. 2 for quality of life by the Princeton Review. Rice is also rated as a best value among private universities by Kiplinger’s Personal Finance. To read “What they’re saying about Rice,” go to http://tinyurl.com/RiceUniversityoverview. AddThislast_img read more

Zicklin MBA Ranking Jumps in US News and More – New York

first_img regions: New York City Last Updated Apr 2, 2018 by Jonathan PfefferFacebookTwitterLinkedinemail About the AuthorJonathan PfefferJonathan Pfeffer joined the Clear Admit and MetroMBA teams in 2015 after spending several years as an arts/culture writer, editor, and radio producer. In addition to his role as contributing writer at MetroMBA and contributing editor at Clear Admit, he is co-founder and lead producer of the Clear Admit MBA Admissions Podcast. He holds a BA in Film/Video, Ethnomusicology, and Media Studies from Oberlin College.View more posts by Jonathan Pfeffer Zicklin MBA Ranking Jumps in US News, and More – New York City Newscenter_img Let’s explore some of the most interesting stories that have emerged from New York City business schools this week.U.S. News & World Report Names Baruch College Among Nation’s 2019 Best Graduate Schools – Zicklin NewsThe Baruch College Zicklin School of Business knocked it out of the park in the recently revealed U.S. News & World Report  “2019 Best Graduate Schools” list. The full-time MBA ranked 55th nationwide (moving up two spots from the previous year), 29th nationwide among public institutions, first among public institutions in both NYC and New York state, 3rd in NYC overall, and 5th in New York State overall.The business school’s part-time MBA also ranked 56th nationwide (a 22-spot jump from last year’s list), 34th nationwide among public institutions, first among public institutions in both NYC and New York state, 3rd in NYC overall, and 3rd in New York state overall. Willem Kooyker, Dean of the Zicklin School of Business Dr. H. Fenwick Huss, Ph.D., said in a release:“Graduates of the Zicklin School of Business lead major businesses around the globe. Our student success is based on an ever-evolving curriculum that today includes data science and analytics, machine learning and cybersecurity along with experiential learning opportunities for real-world problem solving and strategic planning.” Read more about Zicklin’s showing in the US News & World Report rankings here.Living Abroad Leads to a Clearer Sense of Self – Columbia Business School BlogSocial scientists from Columbia Business School, Rice, and UNC universities have recently published new research in the journal Organizational Behavior and Human Decision Processes that finds how “living abroad increases “self-concept clarity.”The findings came after the group surveyed roughly 2,000 “participants from online panels and United States and international MBA programs” that had, at one point, studied abroad.Entitled “The Shortest Path to Oneself Leads Around the World: Living Abroad Increases Self-Concept Clarity,” the study reveals that “living abroad triggers self-discerning reflections in which people grapple with the different cultural values and norms of their home and host cultures. These reflections are helpful in discovering which values and norms define who people are and which simply reflect their cultural upbringing.”You can check out the rest of the study here.Goldman Sachs Executive Recounts Journey to Success in Finance – Gabelli ConnectGoldman Sachs President and Co-Chief Operating Officer Harvey M. Schwartz used his recent Fordham Wall Street Council talk as an opportunity to discuss his unlikely journey from a post-high school gym employee to Wall Street innovator as he stands on the precipice of retirement.“Innovation is present in financial services. I think that if you have an interest in solving complex problems for clients or specific areas of markets, there is a unique way to participate. The takeaway should be that if you work hard, people will invest in you.”Glean more wisdom from Schwartz’s talk here. RelatedLooking At New York City’s Best MBA Return on Investment (Pt. I)As real estate in all five boroughs continues to rise, and/or get snapped up by oh-so-wonderful oligarchs, New York City’s pressure cooker reputation has taken a turn for the … banal. Don’t get me wrong; it’s definitely still a town where it’s survival of the fittest. In fact, it might…November 8, 2017In “Featured Home”The Differences Between a Full-Time MBA in New York City and TorontoNew York and Toronto are the largest cities in the United States and Canada, respectively. Both are major financial and cultural centers, and home to millions of hard-working students, employees, and businesses. Both metros are also home to a number of quality business schools, each with their own prestigious full-time…February 21, 2018In “Featured Home”RECAP: US News —10 MBA Programs With the Highest Signing BonusesIn this post, we’ll recap the 10 highest MBA signing bonus averages— a list of the U.S. business schools whose MBA graduates leave business school with both high-paying jobs and large signing bonuses.June 8, 2017In “Featured Home”last_img read more

Grandfather Pleads No Contest After 8YearOld Driver Dies

first_img Share this article US  LINKEDINPINTERESTREDDITTUMBLRSTUMBLEUPON   Share Show Discussioncenter_img TROY, Kan.—A northeast Kansas man whose 8-year-old granddaughter was killed in a crash as she drove him home from church has pleaded no contest in her death.The St. Joseph News-Press reports that Dennis Meers, of St. Joseph, entered the plea to an aggravated child endangerment charge last week. Sentencing is set for Feb. 6.The Kansas Highway Patrol says Cadence Orcutt was killed in November 2015 when the car she was driving plunged down an embankment and overturned in rural Doniphan County. Meers was injured.Meers previously was sentenced to two years in the Missouri Department of Corrections for felony driving on a revoked license. In 1996 and 2001, Meers was convicted in Missouri on charges of being a persistent offender for driving while intoxicated. (Shi Yali/Shutterstock) Grandfather Pleads No Contest After 8-Year-Old Driver Dies By The Associated Press December 28, 2016 Updated: December 28, 2016last_img read more

US Navy Identifies Sailor Killed by Helicopter Blade

first_img Show Discussion Share this article  QualityAuto 720p480p360p240pRewind 10 SecondsNext UpLive00:0000:0000:00ChromecastClosed CaptionsSettingsFullscreen  click to watch video Follow Ivan on Twitter: @ivanpentchoukov Share  LINKEDINPINTERESTREDDITTUMBLRSTUMBLEUPON   US News center_img Recommended Video: How Doctors in China Turn into Murderers Navy officials identified on Sunday the sailor killed by a spinning helicopter blade as 32-year-old Lt. James Mazzuchelli.The sailor was a flight surgeon assigned to a helicopter squadron as part of Marine Aircraft Group 39. Mazzuchelli was stationed at Camp Pendleton in southern California. He was previously deployed in Japan.Mazzuchelli is from Orange Park, Florida. He enlisted in the Navy in 2010, Los Angeles Times reported. Lt. James Mazzuchelli (U.S. Navy)“Lt. James Mazzuchelli was an incredibly talented physician and Sailor,” Col. Matthew Mowery, the sailor’s commanding officer, told KGTV. “His contagious enthusiasm, motivation, and love for the Marines and Sailors of HMLA-267 and MAG-39 has been evident in the outpouring of grief at his loss and the support being shown to his family and close friends.”“His willingness to join the Navy and elect to serve faithfully with the Marines should give a sense of pride to all of us who serve our country that we are surrounded by heroes every day,” Mowery added. “James and his contribution to our Corps will be sorely missed.” Mazzuchelli was struck by the spinning blade from a UH-01Y Venom Marine helicopter at Camp Pendleton at 6:10 p.m. on Wednesday, Feb. 21, the Orange County Register reported. He died of his injuries at a hospital on Saturday morning. A UH-1Y Venom helicopter is seen en route to Camp Schwab on Okinawa, in Japan, Nov. 9, 2017. (Cpl. Hailey D. Clay/U.S. Marine Corps via Associated Press)No details about the incident have been released. The incident is under investigation.“My heart goes out to our Sailor’s family as we support them through this difficult time,” said Maj. Gen. Mark Wise, commanding general of 3rd Marine Aircraft Wing.The tragic death is the latest in a series of non-combat training accidents which killed or severely injured several Marines.Though the rate of on-duty training-related accident fluctuates, the rate this year up 60 percent compared to 2014, according to the Naval Safety Center.In the most recent fatal accident, three Marines died in a crash in the Philippine Sea on Nov. 22 last year.From NTD.tv U.S. Navy Identifies Sailor Killed by Helicopter Blade By Ivan Pentchoukov February 26, 2018 Updated: February 26, 2018 A sailor was struck by a spinning blade from a helicopter similar to the one in this photo on Wednesday, Feb. 21, 2018. He died of his injuries three days later. (U.S. Navy)last_img read more

Truck Carrying a Load of Candy Flips on Its Side on Busy

first_img Truck Carrying a Load of Candy Flips on Its Side on Busy NJ Highway By Jack Phillips August 29, 2018 Updated: August 29, 2018  LINKEDINPINTERESTREDDITTUMBLRSTUMBLEUPON   A tractor-trailer filled with candy crashed on Route 27 in Mahwah, New Jersey, according to reports.The footage shows the truck turning over on its side before hitting the median in a plume of smoke.The Mahwah Police Department released the footage on Aug. 28.The driver of the candy-filled truck had been aggressively changing lanes, the Mahwah-Ramsey Daily Voice reported.The dashcam video “underscores the dangers of an increasing trend of road-rage incidents,” Police Chief James N. Batelli told the publication.No one was seriously injured in the incident, the report said. The driver of a gray colored SUV “observed what he believed to be a tractor-trailer [driver] driving in an aggressive manner and changing lanes in a reckless manner,” the chief said. The SUV driver “decided to take the matter in his own hands and slow the tractor-trailer down to prevent any type of accident,” he addedBatelli said the tractor-trailer driver that the SUV driver cut in front of him and applied his brakes forcing him to slam his brakes.“Miraculously no other vehicles struck the tractor, which could have resulted in a major accident event,” Batelli said.He added that it‘s fortunate that “no one was injured in this accident and that the substance he was carrying did not contain any hazardous or combustible materials.”The truck driver, a 36-year-old, was cited for careless driving, failure to maintain lane, and failure to signal. The SUV driver got summonses for reckless driving, failure to maintain lanes, failure to signal, and delaying traffic, according to the Daily Voice.Video Credit: Mahwah Police Department via Storyful Share US News center_img Show Discussion Share this article QualityAuto 720p480p360p240pRewind 10 SecondsNext UpLive00:0000:0000:00ChromecastClosed CaptionsSettingsFullscreen  click to watch video last_img read more