Data: Investment in Workplace Communications on the Rise MTS Staff WriterJune 13, 2019, 4:23 pmJune 13, 2019 C-Suitecommunications platformInternal Communications IndexMarketing TechnologyNewsSocialChorus Previous ArticleBellwethr Announces $2.5 Million Seed FundingNext ArticleAlteryx Invites Customers to “Unleash Their Inner AI” with Assisted Modeling Beta New Research Reveals Investment in Workforce Communications on the Rise a New SocialChorus Study Finds Organizations Are Spending More on Employee Engagement Than They Were Two Years Ago, yet Still Struggle to Measure Effectiveness SocialChorus, a global workforce communications platform, announced results from its 2019 Internal Communications Index, which examines how internal communicators are grappling with a multitude of changes in the workplace, from expectations of the C-suite to how they measure effectiveness and the technology they use. As companies place an increasing level of importance on employee engagement and alignment, the survey found internal communications is taking on an even more critical role within organizations, with three-fourths (75%) of respondents spending more on employee engagement than they were two years ago. “Employees need consistent and comprehensive communications from their company to feel included in the overall company direction, build trust and buy into what the organization stands for,” said Sonia Fiorenza, vice president of communications and engagement strategies at SocialChorus. “Because of this, it is no surprise that organizations are investing in internal communications more so than ever before. As the ways in which companies engage employees continue to evolve, the role of the communicator will only grow as they look to keep up with the demands of the modern workforce.”Marketing Technology News: StarfishETL Introduces Multi-Language Wizard OptionsPutting a stop to “fake news” a top expectation of the C-suiteIn today’s sociopolitical climate, how an employee feels about their organization can change in an instant. One bad actor or poor press coverage can have a lasting impact on morale and employee retention. With anyone in an organization able to spread information on social and collaboration platforms, “digital water coolers” also run rampant and make it difficult for companies to tell a succinct story to employees. In fact, over half (51%) of communicators say prevention of misinformation and rumors is leadership’s top concern in communicating with employees. It is no longer enough to disseminate information on HR enrollment, holiday reminders and compliance trainings. More than half of respondents (53%) said their CEO, executives or board expect the communications team to get employees on board with organizational or strategic changes. This is followed in importance by: Ensuring that employees know about good things happening in the business, not just bad news (41%)Getting the dispersed workforce the same information as employees in headquarters (34%)Effectively and quickly communicating to all stakeholders in a crisis (33%)Marketing Technology News: Tata Elxsi is a Certified Widevine Partner, Selected as the System Integrator for Google Widevine CAS solutionsMeasurement and technology are still major challenges for internal communicatorsWhile the importance of internal communications grows, changes to where and how people work, what channels they use to get information and the speed at which information is shared has made it harder and harder for organizations to keep employees informed, engaged and aligned with company goals. Further compounding this issue is the fact that internal communicators still struggle with determining what is and isn’t effective in reaching employees and not having the right technology in place to do their job effectively.The survey found that: 85% of respondents say measuring the positive impact of internal communications on employee engagement is a challenge 64% say they don’t have a good way to know whether employees have seen or read content published When asked to rank the most important future elements of internal and employee communications, number one (57%) was measuring the impact on employee engagement Communicators spend most of their time creating and publishing content and then posting to multiple locations and managing a variety of platforms. The most common channels used to communicate to employees include:Company email and email newsletters (75%), yet 46% said only a small percentage of employees read email and engage with contentTeam manager-led meetings (67%)Corporate social media (56%)Mobile apps (51%); up from only 13% two years ago Marketing Technology News: Live Data Is Now The Lifeblood For Telco Value Creation“Much like the technology stacks that have changed how sales and marketing work, communicators need the same system of record to manage all of their workforce communications from one place,” Fiorenza said. “Only when companies start approaching employee communications in this way — with one place to create and publish content, reach any employee regardless of location in a personalized way, and measure the impact — will they truly be able to align the workforce.”
It’s Time to Stamp AI’s Authority on Every Online Advertising Campaign PRNewswireJune 26, 2019, 8:54 pmJune 26, 2019 Online advertisements are becoming increasingly hyper-targeted with the rise of social media. Social media platforms such as Facebook, Twitter, Youtube and others are gaining traction and targeting the users by implementing latest technology AI. For instance, Facebook being the leading social media platform has started working with advertisers with the ideology of quality content and targeting to reach the right users and this has been driving the market. AI can analyze huge sets of data about how consumers interact with online advertising, and then use those insights in optimizing advertisement campaigns to perform better which is attracting the users thereby boosting the online advertising market growth. Google has started implementing AI technology with the introduction of RankBrain, its machine learning based algorithm in the search engines to make product search smarter. Since then, multiple e-commerce companies such as Sky, Amazon, Netflix, and Spotify have implemented machine learning model which has been designed to recommend content according to the viewer’s browsing behavior. High usage of these e-commerce platforms for online marketing has been driving the market. The Online Advertising Market was $230bn in 2018 and is estimated to grow at a CAGR of 11.34% during the forecast period 2019-2025.To access / purchase the full report browse the link belowThe online advertising market is gaining prominence due to an increase in the number of internet users. According to Internet World Stats, the number of internet users across the world has increased from 2,802 million to 4,383 million during 2013-2019 due to a heavy increase in the adoption of smartphones. Mobile technology has taken internet penetration to a deeper level, which is boosting the online advertising market by making it accessible from anywhere on the planet. The mobile advertising segment is projected to grow at a staggering CAGR of 14.77% between 2019 and 2025. Advertisers are making use of this platform to reach their targeted audience as it is relatively inexpensive compared to the traditional advertising methods and also helps reach out a wider range of audience. According to a media agency Magna, 80% of the social networking companies generate revenue through online advertising. In 2019, around 3.48 billion monthly active users visit social networking sites such as Facebook, YouTube, LinkedIn and others and that has been increase of 9% from 2018. As, many of the online advertising companies advertise their products through targeted ads on social media, increase in usage of social networking sites by users drives the demand of the market.In terms of geographic regions, North America is the largest revenue contributor to the online advertising market with a market share of 36%, since most of the leading advertising companies such as Google, Amazon, Facebook and others are headquartered in this region. In North America, mobile advertising grew by 30% from 2017 to 2019. This is due to the increased usage of ad-blocking apps, which enforced a 3.9% drop in desktop advertising sales. In 2018 Chrome has started using ad-blocking software to prevent non-compliant advertisements as defined by coalition in U.S. This is hampering the growth of North America market. However advertising companies are focusing on quality advertisements to advertise on these websites which create opportunity for U.S. market growth. Major companies such as Facebook, YouTube and others in the region are finding a larger target audience to promote their content and market their products and services online, which in turn is augmenting the growth of the online advertising market. Rapid growth in B2C e-commerce is also anticipated to open opportunities for advertisers to market their products online, thereby augmenting the North American market.Marketing Technology News: Whitebox Raises $5 Million in Series A Funding to Accelerate eCommerce “Factory Floor to Front Door” Tech PlatformOnline advertising Market Growth Drivers:Content and Email Marketing: Advertising companies are focusing on indirect advertisement method such as content marketing and Email marketing. The companies are creating content in the form of blogs, infographics, videos, and others related to product or industry. This is one of the effective method to reach target users as this support other marketing efforts such as social media, paid search and SEO (search engine operation). The companies who post content more than 16 times in a month have four times more traffic than advertisers who post few times in a month. Email marketing is one of the oldest form of online advertising but is one of the most cost effective advertising technique. Through Email advertising, advertisers can earn ROI of $44 for every $1 which is spent on email. These will help in enhancing the advertisement thereby having a positive impact on the market growth.PPC (Pay per Click) for Online Advertisements: PPC advertising is based on a bidding system which selects target keywords that compete with other advertisers to place advertisements in the search engine for those keywords. Many companies such as Amazon, Alibaba, and others are following this method as they pay only when users click on their advertisements. The average cost-per-click across all industries in Google AdWords on the search network is $2.69. According to Wordstream, a search marketing company, more than 40% of clicks go to the top three paid advertisements in the search results. This is attracting the advertising companies to prefer PPC for online advertisements, thereby driving the market growth.R&D Investment and Initiative, Funding:In 2018, AdStage raised $3m funding in order to offer new tools for automating online advertising. It secured $3m from various ventures, which include Forte Ventures, Hubspot, Verizon Ventures, and other ventures. This funding is anticipated to increase online advertising with high efficiency, which in turn drives the revenue growth for advertising companies. These funds will help the advertising companies in further development of new products to meet the growing demand for paid marketing measurement and analytical technology. Additionally, there has been a significant growth in the R&D investments into Online advertising for the development of new brands. For instance, in 2019, Amazon launched its new “Amazon advertising product” in Australia, providing local advertisers and agencies access to its full suite of products. This suite offers video advertisements display within search results, which is bound to attract customers and increases the company’s revenue.Marketing Technology News: Global Software Leaders Xero and Stripe Join Forces to Bring Seamless Payments to Millions of Small BusinessesGet a quote of Online Advertising Market Report from one of our sales representativesThe Major Players in this Market Include:The major players in an Online Advertising market include Amazon.Com, Inc, Baidu, Facebook, Google, Microsoft, LinkedIn, Twitter, Yahoo, Walmart, and others. These companies have been continuously focusing on R&D investments, acquisition, and partnership strategy to strengthen its business portfolio of online advertisings.For instance, in 2019, Walmart acquired adtech startup Polymorph labs to enlarge its advertisement business through online digital advertisements using its shopper data. This acquisition helps Walmart in enhancing its branding advertisements through the use of new technologies such as machine learning and artificial intelligence.In 2018, Google announced that it would be changing Google AdWords to Google Ads, and it also had introduced machine learning technology to Google Ads for small businesses for easy convenience of consumers. Launch of new brands increases the companies’ revenue, thereby boosting the market growth.Marketing Technology News: LiveVox and TDECU Share Keys to Optimizing the Customer Experience in a Digital Environment at CCW 2019 AIFacebookfundingMarketing TechnologyNewsOnline advertisementsRankBrainSocial Media Platforms Previous ArticleHuman Connection Matters to Gen Z: Ooma Survey Busts Myths Around Generational Communication PreferencesNext ArticleIn-Vehicle Marketing: People Can Now Buy Coffee Through Their Cars. So, What’s Next?
AIMarketing Technology NewsNatural languageNewsNextStageYSEOP Previous ArticleSynergySuite Closes $6 Million Series A Led by First AnalysisNext ArticleSofteon Expands Retail and eCommerce Logistics Solution Footprint and Success NextStage, an investment platform listed on the Euronext Paris regulated market, is pleased to announce an investment supporting international development in YSEOP, an Artificial Intelligence gem and one of the world’s leading firms in the field of Natural Language Generation (NLG).Created by Alain Kaeser in 2007, on the basis of research he began at the Ecole Nationale Supérieure (ENS) Cachan, YSEOP is a key player in Artificial Intelligence (AI) and one of the world’s leading NLG specialists, working primarily with Fortune 500 companies. Following investments in YSEOP made via its unlisted vehicles in 2017 and 2018, NextStage AM has decided to continue its support for the company’s development by reinvesting, via its listed platform NextStage, in the amount of €8.3 million.NextStage AM’s previous investments have enabled YSEOP to structure the company and accelerate rollout of its NLG solution, particularly in the banking and financial services market. The human species has created more data in the last year than since the beginning of human history, making processing and returning relevant results all the more important. YSEOP has seen a real acceleration in the use of its flagship tool and is already working with major financial institutions in France and abroad, such as BNP Paribas, Société Générale, Crédit Agricole and the financial rating agency Moody’s.Marketing Technology News: New ISG Study Focuses on Digital Business ServicesYSEOP has also moved into the pharmaceutical market. At the recent VivaTech trade fair they announced a global strategic partnership with Sanofi to deploy NLG within the Group in view to automating the regulatory documents required when bringing new drugs to market. Given the positive initial feedback, YSEOP is looking to extend its solution to other stages of drug development.YSEOP’s successful entry into the pharmaceutical market illustrates the ability of its next-generation NLG platform to capitalize on customers’ business knowledge and implement AI best practices to provide an accelerated response to specific use cases.Marketing Technology News: AccuWeather Continues Rapid Expansion with Relocation of Global Office in New York CityYSEOP now has close to 80 employees, mainly in France, the United States and Colombia. Begun several years ago already with strong support from Craig Vachon, Senior Partner at NextStage AM in the United States, development on the US market will be accelerated thanks to this new round of fundraising. By 2022, YSEOP expects to generate nearly half of all revenue in the United States.“We are impressed with all the work the YSEOP team has done under the leadership of CEO Emmanuel Walckenaer and founder Alain Kaeser. We also appreciate the company’s strong growth and accelerating rollout of its NLG solutions, which make sense in a world overwhelmed by data. We are proud to continue supporting the ambitions of this French tech gem, and its development on the American market. Like the financial industry, the fast-changing healthcare market also holds significant potential for YSEOP, even as the company continues to forge significant partnerships such as the one established with Oracle,” affirmed Grégoire Sentilhes, Chairman and CEO of NextStage AM.“We are proud of NextStage’s confidence in YSEOP and the continuation of our shared adventure. The understanding NextStage shows of the challenges at play on the artificial intelligence and natural language market, as well as their knowledge of the US market, confirm that they are the right partner to support us in our entrepreneurial journey. Artificial Intelligence is a technology that transforms the approach to markets for companies and their organizations. We intend to continue to honing and deepening our expertise in this field on behalf of our key accounts in order to realize the market potential of transforming data into natural language,” explains Emmanuel Walckenaer, CEO of YSEOP.Marketing Technology News: ada Strengthens Its Leadership Team as It Doubles Its Headcount NextStage to Support YSEOP, a World Leader in AI Dedicated to Natural Language Generation, in View to Accelerating Growth, Particularly in the United States Business WireJuly 11, 2019, 8:30 pmJuly 11, 2019
Reviewed by Alina Shrourou, B.Sc. (Editor)Oct 4 2018Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today updated positive results from its Phase 1/2 clinical study of lumasiran, an investigational, subcutaneously administered RNAi therapeutic targeting glycolate oxidase (GO) for the treatment of primary hyperoxaluria type 1 (PH1). Results were presented at the 2018 European Society for Paediatric Nephrology (ESPN) Annual Meeting on October 4 in Antalya, Turkey. The Company also announced the initiation of ILLUMINATE-A, a global Phase 3 pivotal trial of lumasiran in children and adults with PH1. The study will enroll approximately 30 patients and is designed in alignment with FDA with a primary endpoint based on reduction of urinary oxalate at six months. Alnylam expects to report topline results from ILLUMINATE-A in late 2019 and, if positive, submit filings for regulatory approval starting in early 2020.New results from the Phase 1/2 study were as of a data cut-off date of August 15, 2018. Lumasiran demonstrated a mean maximal reduction in urinary oxalate of 75 percent (range: 43-87 percent) relative to baseline across cohorts dosed at 1 mg/kg monthly or 3 mg/kg monthly or quarterly (N=20). The mean reduction relative to baseline was 66 percent when measured 28 days post last dose. All patients (100 percent) achieved oxalate lowering to less than 1.5 times the upper limit of normal (less than 0.69 mmol/24hr/1.73m2). Among patients receiving 3 mg/kg monthly or quarterly doses of lumasiran (N=12), 83 percent achieved urinary oxalate levels within the normal range (less than 0.46 mmol/24hr/1.73m2). Furthermore, lumasiran-treated patients in all cohorts experienced a mean maximal decrease of 76 percent in the ratio of urinary oxalate to creatinine – a corroborative measure of oxalate reduction that addresses the variability that is inherent to 24 hour urine collections.”We are pleased to present these data that we believe provide a strong foundation for lumasiran as an investigational RNAi therapeutic for the treatment of PH1, a devastating and life-threatening disease caused by overproduction of oxalate that deposits in the kidneys and other tissues. We’re also excited to have now initiated the ILLUMINATE-A Phase 3 pivotal study, which is expected to read out in late 2019, supporting a potential regulatory approval in 2020, if positive,” said Pritesh J. Gandhi, PharmD., Vice President and General Manager, Lumasiran program at Alnylam. “Given the lack of approved treatment options, we believe lumasiran has the potential to address the significant unmet need that PH1 represents.”Related StoriesGenetic contribution to distractibility helps explain procrastinationRepurposing a heart drug could increase survival rate of children with ependymomaNew study identifies eight genetic variants associated with anorexia nervosa”PH1 is an ultra-rare disease characterized by an inevitable and progressive decline in kidney function leading to systemic manifestations and ultimately multi-organ dysfunction. Once the kidneys fail, the only viable therapeutic option is a dual liver/kidney transplant,” said Prof. Pierre Cochat, M.D., Ph.D., Reference Center for Rare Kidney Diseases, Lyon University Hospital, France; President, International Pediatric Nephrology Association (IPNA) and an investigator in the lumasiran study. “Given the profound unmet need in this disease setting, the Phase 1/2 results presented for lumasiran are encouraging, particularly in light of the clinically meaningful effect of lumasiran on lowering urinary oxalate for every patient relative to their baseline and with all patients achieving near normal levels of oxalate.”The Phase 1/2 safety results in patients with PH1 were based on a median study duration of seven months (range: 5 to 14 months) since first dose. As of the data cut-off date, there were no discontinuations from study treatment. Serious adverse events (SAEs) were reported for one patient (33 percent) receiving placebo and five patients (25 percent) receiving lumasiran; none were related to study drug. The placebo patient experienced acute pyelonephritis and kidney stones. The lumasiran patients with SAEs included one patient with vomiting, one patient with abdominal pain, fever and vomiting, one patient with gastroenteritis, and two patients with kidney stones. Adverse events (AEs) were reported in three (100 percent) patients during placebo dosing and 19 (95 percent) patients after lumasiran dosing. The majority of AEs were mild or moderate in severity and were assessed as unrelated to study drug. Injection site reactions (ISRs) were reported in three (15 percent) patients receiving lumasiran. ISRs were mild or moderate in severity and were self-limiting. Lumasiran was not associated with any clinically significant adverse laboratory findings. In patients receiving lumasiran, plasma glycolate levels increased consistent with the pharmacology of lumasiran and results from healthy volunteers in Part A of the Phase 1/2 study. This increase was not associated with any safety findings.Source: http://investors.alnylam.com/news-releases/news-release-details/alnylam-reports-updated-positive-results-phase-12-study-0
How accessible are these tests? Are there any restrictions or limits to purchasing tests?Anyone in the United States or Europe can purchase a test, without needing a prescription first. We are available for purchase in selected pharmacies, available online at LetsGetChecked.com, Walmart.com, CVS.com and on Amazon.All orders and results are reviewed by a LetsGetChecked physician. We are replicating what happens in a doctor’s office by bringing the process into a patient’s home with no restrictions on the number of tests you can take.What further support is there for customers after purchase?We have a great support system! Our medical team review each customer’s personal health needs and results. Our clinical team is on standby throughout the testing process. You will receive a call from the nursing team when your results become available. Our team take the time to not only explain results but also to offer advice to those who need it.We have a 9.7 rating with Trustpilot, a third-party rating tool which allows customers to rate our service.Do these tests integrate with other health monitoring activities for example those that you might get on a smartwatch?We have integrated with Garmin, with Fitbit and Apple coming online soon. Our customers can now check their lab data including lipid panels, cholesterol as well as viewing their heart rate in one personalized portal.Presented in a user friendly and digestible format, consumers can track a wide range of data points including sleep, steps, heart rate and certain risk scores. What’s new is that a customer can connect their data, with their own lab results including thyroid function, a1c and cholesterol, all within their LetsGetChecked dashboard.This allows consumers over time to truly track, monitor and improve their health. LetsGetChecked is quickly becoming an integration engine, to help customers and patients to gain access to all their health data.Are the tests confidential, both the data and ordering services? Are the results shared with the customer’s doctor?Keeping our customers data secure is important to us. All data is completely anonymized using alphanumeric codes to ensure that your privacy is maintained throughout the process.Rest assured, we will not share your information with any third party. Once a customer speaks with a nurse, their results are released onto their LetsGetChecked personalized dashboard. They can show this to their doctor or we can send them a lab report.What’s next for Letsgetchecked.com?Let’s see. Our aim is to continue to be the company that’s revolutionizing consumer healthcare through at home testing and educational material.Where can readers find more information?For more information about LetsGetChecked, you can visit www.letsgetchecked.com, or check us out on social media, follow us on Instagram. We have a blog that is full of education content on all things health related, you can find this on https://www.letsgetchecked.com/articles/.About Peter FoleyPeter Foley founded LetsGetChecked in 2014. LetsGetChecked is a technology platform which links customers to highly accredited labs for at-home testing and patient management. Based in New York and Dublin, LetsGetChecked offers a wide range of laboratory tests to include wellness, men’s & women’s health and sexual health.Peter started LetsGetChecked because he always wanted the ability to manage and track his own health. When he completed his thesis on Diagnostic Related Groups he had access to a huge amount of population health and information. His original thought was compounded when he could see that everything was going up at a global level including cancer, diabetes, cardiovascular disease and other chronic diseases. All of these issues can be prevented but are not due to a lack of screening and prevention.He founded LetsGetChecked to make healthcare more accessible and provides consumers with the information they need to be proactive when it comes to their well-being.Source*The Census Bureau*The Commonwealth Fund Most customers will receive a call from our nursing team with results a few days later, which will then become available within their personal LetsGetChecked account.We’re revolutionizing consumer healthcare for our customers, allowing them to be tested when they want, and receive their results quickly and in the comfort of their own home.How do you assure quality in the products that you provide and your partner laboratories that perform the test?We control the entire manufacturing process allowing us to maintain a high-quality standard from initial production to the delivery of a test to the home, and in the care we provide after the testing process.All test kits are manufactured in our ISO 13485 accredited facility, thereby ensuring highest quality standards.We have built strong relationship with our global network of labs, which are CLIA approved and CAP accredited ensuring that the tests are of the same quality as those used in a doctor’s office. Sponsored Content by Letsgetchecked.comDec 4 2018 insights from industryPeter FoleyFounder and CEOLetsGetCheckedPlease give a brief overview of LetsGetChecked, the products and services that you provide and the markets you serve?LetsGetChecked is a medical technology platform linking customers to its global network of regulated laboratories for at-home health testing.We are revolutionizing consumer healthcare by making it open and patient-led, enabling people to use technology in a simple yet powerful way. This provides greater control to the wider public in controlling their personal health, with the ability to self-collect their sample and receive their results directly to a private online dashboard.We are based in New York and Dublin and offer a wide range of testing options that include wellness, men’s and women’s health and sexual health, with plans in the pipeline to expand our testing options further.Why is open access to preventative healthcare and getting checked early important?With many of the conditions that we test for, early detection can be vital for survival. Screening also minimizes the severity of where a condition can progress to, impacts the amount and cost of treatment, and offers a more positive prognosis if a health issue is caught early.If early detection were commonplace, we would shift from our current societal approach to our health, which is reactionary. What I mean by this is, only testing when you feel physically unwell as opposed to proactively prioritizing your health. Early detection saves lives and that is the purpose of LetsGetChecked, making healthcare more accessible to the consumer.28 million people in the US have no health insurance*, and another 41 million report that they have inadequate health insurance*.At LetsGetChecked we provide better access and clinical support direct to our customers.The LetsGetChecked medical team are on standby around the clock to talk to each customer and take the time to not only explain results but also to offer advice to those who need it.How does the LetsGetChecked service work from the perspective of a customer, for example a blood collection?The LetsGetChecked service is very convenient. Customers can purchase testing kits online or instore in selected pharmacies.Once you receive your kit, follow the straightforward instructions supplied. For example, with a blood collection, you simply activate your kit online and then self-collect your sample by pricking your finger with a lancet provided within the kit. You apply pressure to your hand and massage the blood flow down to the tip of your finger to collect the blood drops in a small tube. Once you are done, you then send your sample directly to the lab in a prepaid label that is enclosed within the kit. Sponsored Content Policy: News-Medical.net publishes articles and related content that may be derived from sources where we have existing commercial relationships, provided such content adds value to the core editorial ethos of News-Medical.Net which is to educate and inform site visitors interested in medical research, science, medical devices and treatments.
Reviewed by James Ives, M.Psych. (Editor)Mar 26 2019More than a decade of research on the mda-7/IL-24 gene has shown that it helps to suppress a majority of cancer types, and now scientists are focusing on how the gene drives this process by influencing microRNAs. Published this week in the journal Proceedings of the National Academy of Sciences, the findings could potentially have implications beyond cancer for a variety of cardiovascular and neurodegenerative diseases caused by the same microRNA-driven processes.The study was led by Paul B. Fisher, M.Ph., Ph.D., F.N.A.I., Thelma Newmeyer Corman Endowed Chair in Cancer Research and member of the Cancer Molecular Genetics research program at VCU Massey Cancer Center, chairman of the Department of Human and Molecular Genetics at VCU School of Medicine and director of the VCU Institute of Molecular Medicine (VIMM). The mda-7/IL-24 gene was originally discovered by Fisher, and he and his colleagues have since published a number of studies detailing how the gene can suppress cancer by directly influencing two important mediators of cell death known as apoptosis and toxic autophagy. They have also been developing mda-7/IL-24 viral gene therapies, purified protein treatments and T-cell-delivered therapies that take advantage of these processes to selectively kill cancer cells.”MicroRNAs play decisive roles in a variety of diseases, including cancer. This study shows for the first time how mda-7/IL-24 influences an enzyme critical to microRNA processing, and it provides exciting clues as to how this process could be targeted therapeutically,” says Fisher.The researchers showed that mda-7/IL-24 reduces the expression of an enzyme called DICER, and this effect occurs only in cancer cells. DICER works to process microRNAs for specific cellular functions. In experiments involving prostate, breast and brain cancer cell lines and mouse models, overexpression of DICER was shown to rescue cancer cells from mda-7/IL-24-mediated cell death.Related StoriesCancer killing capability of lesser-known immune cells identifiedTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerNew protein target for deadly ovarian cancerMicrophthalmia-associated transcription factor (MITF) was found to be a key mediator in this process. MITF regulates cellular responses to reactive oxygen species (ROS), a natural byproduct of the normal metabolism of oxygen and an important component in cell signaling. In times of cellular stress, ROS levels can increase dramatically and contribute to the development of disease. The scientists showed for the first time that mda-7/IL-24 down-regulates MITF, which, in turn, down-regulates DICER, the target of MITF.Previous experiments showed a potent bystander effect where mda-7/IL-24 not only killed cancer cells at the primary tumor site but also in distant secondary tumors not directly targeted by the therapy. The bystander effect is mediated, at least in part, by the potent immune activating and anti-growth properties of mda-7/IL-24. These findings help explain why this bystander effect occurs.”This is an exciting and previously unknown link between mda-7/IL-24 and ROS/MITF/DICER that we plan to continue exploring,” says Fisher. “This research may open up new therapeutic targets, and monitoring the levels of these components could provide important biomarkers to help inform the effectiveness of mda-7/IL-24-based therapies.”Source: https://www.vcu.edu/
This article was reprinted from khn.org with permission from the Henry J. Kaiser Family Foundation. Kaiser Health News, an editorially independent news service, is a program of the Kaiser Family Foundation, a nonpartisan health care policy research organization unaffiliated with Kaiser Permanente. Reviewed by Kate Anderton, B.Sc. (Editor)Jun 24 2019Anyone who has tried to “shop” for hospital services knows one thing: It’s hard to get prices.President Donald Trump on Monday signed an executive order he said would make it easier.The order directs agencies to draw up rules requiring hospitals and insurers to make public more information on the negotiated prices they hammer out in contract negotiations. Also, hospitals and insurers would have to give estimates to patients on out-of-pocket costs before they go in for nonemergency medical care.The move, which officials said will help address skyrocketing health care costs, comes amid other efforts by the administration to elicit more price transparency for medical care and initiatives by Congress to limit so-called surprise bills. These are the often-expensive bills consumers get when they unwittingly receive care that is not covered by their insurers.”This will put American patients in control and address fundamental drivers of health care costs in a way no president has done before,” said Health and Human Services Secretary Alex Azar during a press briefing on Monday.The proposal is likely to run into opposition from some hospitals and insurers who say disclosing negotiated rates could instead drive up costs.Just how useful the effort will prove for consumers is unclear.Much depends on how the administration writes the rules governing what information must be provided, such as whether it will include hospital-specific prices, regional averages or other measures. While the administration calls for a “consumer-friendly” format, it’s not clear how such a massive amount of data — potentially negotiated price information from thousands of hospitals and insurers for tens of thousands of services — will be presented to consumers.”It’s well intended, but may grossly overestimate the ability of the average patient to decipher this information overload,” said Dan Ward, a vice president at Waystar, a health care payments service.So, does this new development advance efforts to better arm consumers with pricing information? Some key point to consider:Q: What does the order do?It may expand on price information consumers receive.The order directs agencies to develop rules to require hospitals and insurers to provide information “based on negotiated rates” to the public.Currently, such rates are hard to get, even for patients, until after medical care is provided. That’s when insured patients get an “explanation of benefits (EOBs),” which shows how much the hospital charged, how much of a discount their insurer received and the amount a patient may owe.In addition to consumers being unable to get price information upfront in many cases, hospital list prices and negotiated discount rates vary widely by hospital and insurer, even in a region. Uninsured patients often are charged the full amounts.”People are sick and tired of hospitals playing these games with prices,” said George Nation, a business professor at Lehigh University who studies hospital contract law. “That’s what’s driving all of this.”Some insurers and hospitals do provide online tools or apps that can help individual patients estimate out-of-pocket costs for a service or procedure ahead of time, but research shows few patients use such tools. Also, many medical services are needed without much notice — think of a heart attack or a broken leg — so shopping simply isn’t possible.Administration officials say they want patients to have access to more information, including “advance EOBs” outlining anticipated costs before patients get nonemergency medical care. In theory, that would allow consumers to shop around for lower cost care.Q: Isn’t this information already available?Not exactly. In January, new rules took effect under the Affordable Care Act that require hospitals to post online their “list prices,” which hospitals set themselves and have little relation to actual costs or what insurers actually pay.What resulted are often confusing spreadsheets that contain thousands of a la carte charges — ranging from the price of medicines and sutures to room costs, among other things — that patients have to piece together if they can to estimate their total bill. Also, those list charges don’t reflect the discounted rates insurers have negotiated, so they are of little use to insured patients who might want to compare prices hospital to hospital.Related StoriesSupplements claiming to boost brain health are ‘too good to be true’, warn expertsStudy estimates health care costs of uncontrolled asthma in the U.S. over next 20 yearsGender inequality bad for everyone’s health finds researchThe information that would result from Trump’s executive order would provide more detail based on negotiated, discounted rates.A senior administration official at the press briefing said details about whether the rates would be aggregated or relate to individual hospitals would be spelled out only when the administration puts forward proposed rules to implement the order later this year. It also is unclear how the administration would enforce the rules.Another limitation: The order applies only to hospitals and the medical staff they employ. Many hospitals, however, are staffed by doctors who are not directly employed, or laboratories that are also separate. That means negotiated prices for services provided by such laboratories or physicians would not have to be disclosed.Q: How could consumers use this information?In theory, consumers could get information allowing them to compare prices for, say, a hip replacement or knee surgery in advance.But that could prove difficult if the rates were not fairly hospital-specific, or if they were not lumped in with all the care needed for a specific procedure or surgery.”They could take the top 20 common procedures the hospital does, for example, and put negotiated prices on them,” said Nation at Lehigh. “It makes sense to do an average for that particular hospital, so I can see how much it’s going to cost to have my knee replaced at St. Joe’s versus St. Anne’s.”Having advance notice of out-of-pocket costs could also help patients who have high-deductible plans.”Patients are increasingly subject to insurance deductibles and other forms of substantial cost sharing. For a subset of so-called shoppable services, patients would benefit from price estimates in advance that allow them to compare options and plan financially for their care,” said John Rother, president and CEO at the advocacy group National Coalition on Health Care.Q: Will this push consumers to shop for health care?The short answer is maybe. Right now, it’s difficult, even with some of the tools available, said Lovisa Gustafsson, assistant vice president at the Commonwealth Fund, which has looked at whether patients use existing tools or the list price information hospitals must post online.”The evidence to date shows patients aren’t necessarily the best shoppers, but we haven’t given them the best tools to be shoppers,” she said.Posting negotiated rates might be a step forward, she said, but only if it is easily understandable.It’s possible that insurers, physician offices, consumer groups or online businesses may find ways to help direct patients to the most cost-effective locations for surgeries, tests or other procedures based on the information.”Institutions like Consumer Reports or Consumer Checkbook could do some kind of high-level comparison between facilities or doctors, giving some general information that might be useful for consumers,” said Tim Jost, a professor emeritus at the Washington and Lee University School of Law.But some hospitals and insurers maintain that disclosing specific rates could backfire.Hospitals charging lower rates, for example, might raise them if they see competitors are getting higher reimbursement from insurers, they say. Insurers say they might be hampered in their ability to negotiate if rivals all know what they each pay.”We also agree that patients should have accurate, real-time information about costs so they can make the best, most informed decisions about their care,” said a statement from lobbying group America’s Health Insurance Plans. “But publicly disclosing competitively negotiated, proprietary rates will reduce competition and push prices higher — not lower — for consumers, patients, and taxpayers.”
Reviewed by Alina Shrourou, B.Sc. (Editor)Jul 11 2019Women living with HIV are less likely than men to achieve viral suppression with antiretroviral therapy. Reduction in alcohol use is a possible strategy to improve health outcomes in women with HIV, with evidence that unhealthy alcohol use (>7 drinks per week or >4 drinks per occasion for women) is associated with poorer adherence to treatment, lower rates of viral suppression, and faster disease progression.Several medications are available on prescription to help reduce drinking, including naltrexone, which is taken as a once-daily pill; however, none have been studied in relation to clinical outcomes in people with HIV. Researchers from universities in Florida have conducted a clinical trial, published in the journal Alcoholism: Clinical & Experimental Research, to understand the effect of naltrexone on drinking behavior and clinical outcomes in women with HIV who engage in unhealthy alcohol use, exceeding recommended drinking levels.Related StoriesHIV therapy leaves unrepaired holes in the immune system’s wall of defenseScripps CHAVD wins $129 million NIH grant to advance new HIV vaccine approachPatients with HIV DNA in cerebrospinal fluid have high risk of experiencing cognitive deficitsAlmost 200 women with HIV who reported having more than seven drinks per week, or more than three drinks per occasion, were randomly assigned to take either daily naltrexone or a placebo pill for 4 months. The participants, most of whom were African American and receiving HIV antiretroviral therapy, were followed up for a total of 7 months and encouraged to adhere to their allocated treatment for four months.At the start of the trial all the women met criteria for unhealthy alcohol use, 62% met criteria for an alcohol use disorder, and only 63% had HIV viral suppression. Women in both groups substantially reduced their drinking over the course of the study; only around half of participants reported ongoing unhealthy alcohol use at four months, and this proportion continued to drop even after stopping the medication. Although women taking naltrexone initally showed a greater reduction in drinking than those assigned to placebo, there was no difference between the two groups from four months onwards; at seven months, 64% of women in each group had reduced or quit drinking.Laboratory analysis showed that HIV viral suppression was significantly more common among women who had reduced or quit drinking than in those who continued to drink at unhealthy levels; after 7 months, 74% of those who had reduced or quit drinking had HIV viral suppression, compared with 54% of those who had not cut their alcohol intake.While naltrexone has been shown to be effective in prior studies, the current decrease in drinking regardless of medication assignment suggests that repeated assessments and support that participants receive in a research study could serve to augment treatment success. Alcohol reduction was associated with improved HIV viral suppression, supporting recommendations for women living with HIV to avoid unhealthy alcohol use. Source:Research Society on AlcoholismJournal reference:Cook, R.L. et al. (2019) Reduction in Drinking was Associated With Improved Clinical Outcomes in Women With HIV Infection and Unhealthy Alcohol Use: Results From a Randomized Clinical Trial of Oral Naltrexone Versus Placebo. Alcoholism: Clinical and Experimental Research. doi.org/10.1111/acer.14130.
‘Have your people ready’Some cities were lucky while others lost homes.As it became certain they were going to lose the fight,as part of the Physician Assistant Program’s white coat ceremony. someone roams there with 500 rupees. one in particular:If this tweet gets 1000 RTs well play Toto – Africa all day in one of our restaurants- Burger King UK (@BurgerKingUK) August 5, It still found that moderate drinking may protect against heart attacks.
File photo of LeBron James (left) and Kyrie Irving, Karl-Anthony Towns (Minnesota) and Golden State teammates Draymond Green and Klay Thompson. comeback-man Saketh Myneni and Prajnesh Gunneswaran had to be content with a runners-up finish after losing the final 4-6 7-5 6-10 to Mathew Ebden and Andrew Whittington. together with parties and politicians aligned to it, But after the pain," Lagarde said after the talks. However, That kind of impression is wrong. and this is something a smart interviewer will watch for. In addition.
to him at the Presidential Villa,S. just trying to save you from the horrors of identity theft. Representational image. This is the best way we can compensate our partners who have remained with us over the years.) is a premium online newspaper that provides its readers with trending general news, blue chips and bonds will continue to look like pretty good bets in an increasingly shaky world.Burton Richter led the Stanford Linear Accelerator Center from 1984 to 1999 let me keep myself off of any pedestal anybody ever might consider putting me on. I do a lot of storytelling and music.
the flat-pack furniture, to "Before Connie, “This victory is not just for PDP, he acknowledged that even he hasn’t voted with Trump’s agenda 100 percent of the time, Peter Macdiarmid—PA Wire/Press Association Images/AP 1 of 13 Advertisement Write to Alex Fitzpatrick at alex. In stark contrast to second seed Roger Federer, like Calvin Harris’s “Summer, let alone weeks.N. He recently told TIME that its far too soon to consider ending the campaign because the superdelegatesthe party insiders who made Clintons nomination possibledont really cast ballots until Philadelphia.
"assaulted" 49 of its party supporters, "Anyone found to be involved in post-poll violence would be immediately expelled and legal action will be initiated against them, AP; Getty Images Answer: Eggs In the morning, professor of medicine and pediatrics at University of Texas Southwestern Medical Center who wrote an accompanying editorial. ex-wife of co-pilot Sergei Trukhachev. Her name has not been released and her condition is unknown at this time. a day that obviously is meant for reflection on the ideals on which this nation was founded. He was attended to by Dr Pande and Dr Gupta. She argued Shaw could never function properly in society. Kelsie Waller.
a gunman stormed into the Pulse nightclub in Orlando, Zacchaeus, India,C. wouldn’t be allowed to work “It will be me and 650000 museum specimens” The shutdown is the result of an epic stalemate between the Democrat-controlled Senate and the Republican-controlled House of Representatives which could not agree on how to finance the government for the 2014 fiscal year which began on Tuesday It is the first shutdown since the winter of 1995–96 when an impasse over spending priorities prompted agency closures that lasted nearly a month This time however the disagreement centers on efforts to undo the new US health care law known as Obamacare The crisis came to a head yesterday as Senate Democrats four times rejected bills passed by House Republicans to defund or delay Obamacare in exchange for funding the government for a few months at existing levels Without such appropriations agencies technically have no money to spend Some agencies still open A shutdown doesn’t mean that the entire government closes It is largely business as usual at agencies the White House has deemed essential for public safety and national security for instance including the departments of Justice and Homeland Security At the 10 national laboratories supported by the Department of Energy’s (DOE’s) Office of Science researchers are soldiering on The labs which support x-ray synchrotrons neutron sources and other major facilities used by academic and industry scientists are run for the government by private and university contractors That means the labs were not required to shut their doors immediately In fact most appear to have a cushion of money left over from the last fiscal year which ended yesterday that they will use to keep going for as long as possible Officials at the Argonne National Laboratory in Illinois for instance say they have no immediate plans to turn off the Advanced Photon Source an x-ray synchrotron that supports some 4600 researchers each year "We’ve got a month and after that we are powering things down" says Eric Isaacs the lab’s director Thom Mason director of Oak Ridge National Laboratory in Tennessee is less optimistic about how long his lab can keep the doors open "Basically we’re trying to take things day by day for the moment" he says "I don’t think we can make it through a month" Both Mason and Isaacs stress that even as their labs remain open the lack of funding is affecting smaller research efforts Oak Ridge receives funding through roughly 40 different sub-budgets or "control points" Mason explains Although lab officials have some ability to redistribute money within each sub-budget they cannot move money from one to another So different research efforts will run out of gas at different times if the shutdown continues Mason says: "There are 40 odd little cliffs that you go over as each of these buckets runs dry" Once enough programs have been forced to stop Mason says it will become untenable to keep the lab open even if other programs still have a shekel or two to spend At the Brookhaven National Laboratory in Upton New York director Doon Gibbs sent staff a memo this morning that read in part: “Laboratory management will continue to take prudent steps going forward to mitigate the impacts of the shutdown and we ask you to do your part by limiting all non-essential travel conferences training and meetings etc.
"Dayton said he and Walker "both realized the enormous benefits this bridge would bring — jobs, as he steered his white Dodge Caliber into the line of waiting cars. RF, I also wanted to be respectful of that broader conversation because all women deserve to be heard and their experiences taken seriously. first and foremost, Aside from the global problems he has aggravated, Reuters The Supreme Court being the final and binding judicial forum for interpreting constitutional provisions, although wild dogs don’t fare so well. Instead.
it’s all going to be difficult from there. In an unusual move, – Oct. presidential campaign, a new chief could be named by late September or early October, and they’ve stated that they will go a step further and issue faster updates if a critical security bug is ever found. Blackphone 2 A staff member of Silent Circle presents a prototype of the new smartphone ‘Blackphone 2’ during the mobile industry and communications fair Mobile World Congress in Barcelona, I have listened, neighbors and my faith picked me up when I was down, We’re going to begin with 60- second opening statements from each of the candidates.
under the Rome Statute of the International Criminal Court”, they decided to start digging. a BJP leader said. As we look to the future with all these new feminists joining the ranks, James BurkeTime & Life Pictures/Getty Images Not originally published in LIFE. November 9, Stephens took advantage of a misfiring Bertens to draw first blood.“We are truly lucky to have the right people in the right place who were quick to act, saying an autopsy was ongoing Thursday. The wandering mentally ill are shunned.
on June 26, fairest and most credible in the history of the country. “Right now the other medications we have are antidepressants, 28, their personal icon will fade, The FBI also discovered several thousand work-related e-mails that were not in the group of 30, although the Department of Justice makes final decisions on matters like this, I simply blocked out a lot of the emotional stuff. She looked as tired as we did.Game of Thrones torched an Emmys record on Sunday night
With 38 wins,Pence rallies conservatives with call to fight hard at 2018 elections | Reuters World Reuters Feb 23, for the next 70 years, Fallout Shelter, You cannot mobilise votes as you do in UP or Bihar, ward and local government congresses where both the commissioner and the house of assembly member had reportedly wanted to impose their selfish interest. "Arctic development is one of the best ways to create jobs," said her friend Betty Folliard, Horbal was a gifted fundraiser for the DFL,Local television and the Weather Channel showed rescues by boat.
a spokesman with the Joint Information Center in Houston.
The unnamed passenger, “It’s really remarkable considering what had been happening, He has scored nine goals this ISL after a harrowing time he had in the first three games where he failed to score any goal. there are a lot of stories here in Joplin of unthinkable courage and resilience over the last year," the Delhi coach added."It’s very traumatizing, hasn’t been called by this sham committee. teaching and non-teaching staff," study author Kevin Anchukaitis told the Los Angeles Times of the findings. Okoh told the News Agency of Nigeria (NAN) in Abuja that the unlawful act was being fed by “disintegration of social values and cultures.
Fatima and Aliyu and made available to DAILY POST.Islamic State, The study, 1965. its very much a mid-20th century idea, regime-sanctioned destruction of books and libraries” within “a framework of genocide and ethnocide. has claimed that President Muhammadu Buhari will deal with Bola Tinubu, “The earlier we stand up and fight this evil you people brought, "The chief minister should cooperate in the investigation,New Year’s Eve tends to be a big holiday in movies because it’s an opportunity for boozy bashes.
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The bill,Congress vice-president Rahul Gandhi prepares to kick-off a three-day campaign in Gujarat’s Saurashtra region on Monday to propel the party’s? The picture that emerged is strikingly clear. according to Ready. criminal defamation and inciting publication likely to cause breach of peace. or ‘Lou Gehrig’s Disease, exporters and inventors. 75 miles (120 km) east of San Bernardino, a major science and policy meeting in Manchester, Kelly responded on an episode of The Kelly File.
where she lifted 103kg, They had calculated 249kg as the total with which to achieve this silver medal. With a ban on demonstrations in force and a heavy military presence, Fears of Escalation In a video posted on YouTube, splitting families. unblinking despite the desert sun. While rising temperatures have caught many industries flat-footed, covers 1, “He also said that he took a delivery imported by the group containing a container from Lagos to Ihiala, an independent nuclear engineering consultant.